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Following the inclusion of lcFAODs in NBS panels in many countries worldwide, the number of patients diagnosed has significantly increased and the clinical spectrum has expanded, necessitating new algorithms for choosing the optimal therapeutic strategy

The co-expression of ST and RAS V12 leads to the upregulation of topoisomerase I, thereby increasing cellular susceptibility to Erastin (Yagoda et al., 2007

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It also helps make more collagen in the body, which can make skin stretchy and decrease the look of small lines and wrinkles

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